Zoledronic acid is more commonly known as Reclast, Aclasta or Zometa. This medication works by slowing down osteoclast i.e. bone cells. These osteoclasts generally break down the hard-mineral structure of the bones in order to keep the bones healthy. But when the prostate cancer spreads to bones, these osteoclasts become overactive which cause problems in the body. Zoledronic acid injection (Brand Zometa) is the most commonly used medication for prostate cancer. Zometa / Reclast is generally given once every 3 or 4 weeks as an intravenous injection. This medication is given to men is required to take a calcium supplement and Vitamin D in order to avoid any problem related to low calcium levels.