An essential part of HIV preventive and treatment plans is post-exposure prophylaxis. PEP greatly lowers the risk of HIV transmission by offering a time-limited course of antiretroviral medications following probable exposure. Its success depends on timely beginning, adherence to the regimen, and regular follow-up. Although there are obstacles, initiatives to increase awareness, improve accessibility, and deal with cost-related issues can help PEP have the greatest possible impact, eventually moving the objective of a world free from HIV/AIDS forward.