Register QuickBooks Desktop on 2016 or Newer Versions. Open QuickBooks Desktop to your pc after which press the F2 key to your keyboard. You can also activate it manually with the below-given steps: First of all, Open the QuickBooks and press the “F2” key on the keyboard. Type in the “License Number” and “Product Number” in the information dialogue box, and then select the “Next” tab. Choose the “Register Online” option.